Endocrine Abstracts

Graves' disease is known to occur with increased frequency in patients with Type 1 diabetes mellitus (T1DM) especially women. Undiagnosed thyrotoxicosis can aggravate glucose intolerance and precipitate diabetic ketosis and ketoacidosis. Among the various presenting symptoms of hyperthyroidism, vomiting is a recognized but uncommon symptom.We present the case history of a 30 year old woman with T1DM of 10 years duration presenting with a short history of...

Most cases of primary hyperparathyroidism are due to either parathyroid adenoma or hyperplasia. Parathyroid carcinoma is a rare cause of hyperparathyroidism, usually diagnosed post operatively .Prognosis is poor with a 5 year survival rate of 50-75%.A 74 year old man presented with a 2 week history of weight loss, anorexia and constipation but no abdominal or bone pain. Past history included hypertension and gout and was not on drugs known to cause hyper...

Aim: To assess the outcome of thyroid surgery in a District General Hospital.Methods: Retrospective study of thyroid surgery done over a 3-year period(1999-2002). Indications for surgery, pre and postoperative thyroid status, extent of surgery, post operative complications and post operative histology were evaluated.Results: 124 patients underwent surgery for thyroid disease. 90 % were female and 10 % male, median age of 52 years (...

MicroRNAs (miRNAs) are small non-coding RNAs that repress protein production post-transcriptionally. MiRNAs play crucial roles in metabolism, endocrine cells development and in processes altered in T2D, such as insulin secretion. MiR-125b controls proliferation, apoptosis and differentiation of various cell types, although its role in β-cells remains unclear. Recent studies show an association between high levels of circulating miR-125b and hyperglycaemia (HbA1c) in predi...